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. 2017 Jan 6;17:26. doi: 10.1186/s12885-016-3004-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Intraoperative findings (microscopy) before the first pressurized intraperitoneal aerosol chemotherapy (PIPAC) (a), and during consecutive PIPAC cycles (PIPAC #3 (b), PIPAC #5 (c), and PIPAC #6 (d). Panel A shows peritoneal manifestations of a serous carcinoma with large, pleomorphic nuclei and frequent mitosis. Histopathological specimens taken during consecutive PIPACs 3, 5, and 6 (panels b, c, and d, respectively) show residual peritoneal tumor foci with reduced cellularity and fibroelastic connective tissue and associated inflammatory changes such as fibrinous exudate, fibrosis, foreign-body reaction, and hemosiderin-laden macrophages. Bars, 100 μm