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. 2017 Jan 5;36:3. doi: 10.1186/s13046-016-0480-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Working model of OL action in promoting radiation sensitivity. OL decreases HIF1α expression, which in turn represses miR-519d expression. miR-519d functions to directly target PDRG1 mRNA and inhibit its expression. PDRG1 is able to inhibit radiation sensitivity via the ATM-P53 axis. The overall effect of OL in NPC is then to promote radiation sensitivity