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. 2017 Jan 5;18:2. doi: 10.1186/s12882-016-0427-z

Table 3.

Factors predicting remission of nephrotic syndrome after tacrolimus treatment in univariate and multivariate logistic model

Variables Partial or complete remission Complete remission
OR 95% CI P-Value OR 95% CI P-Value
Univariate logistic models
 Gender (Female vs. Male) 1.6 0.99–2.6 0.06 3.1 1.9–4.9 <0.001
 eGFR at baseline (for every 10 mL/min/1.73 m2) 1.1 1.0–1.2 0.003 1.1 1.0–1.2 0.06
 Proteinuria at the onset of tacrolimus therapy 0.94 0.87–1.0 0.11 0.94 0.86–1.0 0.22
 Previous treated with immunosuppressive drugs (Yes vs. No) 0.42 0.25–0.70 <0.001 0.42 0.19–0.85 0.02
 Average tacrolimus exposure (ng/mL) 1.2 1.1–1.3 0.004 1.2 1.0–1.3 0.005
Multivariate logistic model
 Gender (Female vs. Male) 1.7 1.0–3.0 0.04 3.3 2.0–5.6 <0.001
 Previous treatment with immunosuppressive drugs (Yes vs. No) 0.39 0.22–0.67 <0.001 0.40 0.17–0.83 0.02
 eGFR at baseline (for every 10 mL/min/1.73 m2) 1.2 1.1–1.4 0.001 1.1 0.99–1.2 0.07
 Average tacrolimus exposure (ng/mL) 1.2 1.1–1.3 0.001 1.2 1.0–1.2 <0.001