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. 2004 Sep 30;32(17):5134–5146. doi: 10.1093/nar/gkh846

Figure 4.

Figure 4

Schematic structure of DNA binding site of APE1. The DNA-binding site of the enzyme consists of two sets of ten subsites each, but only one set of subsites interacting with the cleaved strand, shown in the figure, contains a specific subsite (‘0’ subsite) with increased affinity for one specific or nonspecific nucleotide unit of DNA. Lengthening of nonspecific d(pN)n (1 ≤ n ≤ 10) leads to the formation of several alternative thermodynamically comparable complexes of these ODNs with different subsites on the enzyme.