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. 2004 Oct 4;32(17):5163–5173. doi: 10.1093/nar/gkh847

Figure 1.

Figure 1

Sequences of the oligonucleotides used for this study. Sequences of the target 27, 30mer (I), (II) and (III) duplex oligonucleotides and the TFO showing the 3′ radiolabel (cordycepin indicated by 32P-A) on the scissile strand of the duplexes. The TFO binds in the major groove in a parallel orientation to the oligopurine strand of the duplex and is indicated by a dashed arrow. The Top1-mediated DNA cleavage site is indicated by a caret (^), and the nucleotides between the site of cleavage and formation of the triplex are highlighted in bold. M, 5-methyl-2′-deoxycytidine; P, 5-propynyl-2′-deoxyuridine.