Figure 5.

Kaplan-Meier plots of age-at-onset for LHFPL2 (rs344650) and TPM1 (rs117267308). Familial PD (A–D): LHFPL2 genotype and TPM1 genotype show markedly significant effects on age-at-onset of familial PD. Non-familial PD (E–H): Age at onset distributions did not vary by LHFPL2 genotype or by TPM1 genotype in non-familial PD. Kaplan-Meier survival curves are plots of age-specific cumulative probability of survival without disease. Here, survival is defined as not yet being affected with PD, the event is onset of PD, and the time of event is age-at-onset. Patients are divided by genotype (presence vs. absence of the minor allele), and cumulative disease-free survival is plotted for each group. Red: individuals with the minor allele. Blue: individuals without the minor allele.