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. 2017 Jan 1;23(1):72–79. doi: 10.5056/jnm16119

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© 2017 The Korean Society of Neurogastroenterology and Motility

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The study protocol. This study was performed in a prospective, randomized, cross-over design. Subjects participated in 2 separate experiments including the experiment with high-resolution esophageal manometry (HRM) measurement (Experiment I) and the experiment with esophageal multichannel impedance-pH measurement (Experiment II). They underwent esophageal HRM with 10 wet swallows (Experiment I) and esophageal impedance-pH monitoring (Experiment II) in the basal period and in the stress period. In the stress period, either real stress or sham stress was given in a randomized cross-over design . Assessment of stress levels and symptoms, and measurement of pulse rates.

Inline graphic — The study protocol. This study was performed in a prospective, randomized, cross-over design. Subjects participated in 2 separate experiments including the experiment with high-resolution esophageal manometry (HRM) measurement (Experiment I) and the experiment with esophageal multichannel impedance-pH measurement (Experiment II). They underwent esophageal HRM with 10 wet swallows (Experiment I) and esophageal impedance-pH monitoring (Experiment II) in the basal period and in the stress period. In the stress period, either real stress or sham stress was given in a randomized cross-over design . Assessment of stress levels and symptoms, and measurement of pulse rates.