TABLE 3.
Influence of N6AMT1 and As3MT genotypes on fractions of arsenic metabolites and methylation capacity indexes.
| Gene | SNPs | Genotypea | N | % iAs | % MMA | % DMA | PMI | SMI |
|---|---|---|---|---|---|---|---|---|
| N6AMT1 | rs1006903 | GG | 170 | 7.69 (0.53)b | 26.32 (0.94) | 66.00 (1.04) | 0.92 (0.01) | 0.71 (0.01) |
| GC | 105 | 7.52 (0.68) | 25.06 (1.20) | 67.42 (1.33) | 0.93 (0.01) | 0.73 (0.01) | ||
| CC | 14 | 8.66 (1.87) | 30.88 (3.28) | 60.47 (3.64) | 0.91 (0.02) | 0.66 (0.04) | ||
| P-value | .848 | .234 | .189 | .848 | .158 | |||
| rs1003671 | AA | 130 | 8.96 (0.60)*c | 26.32 (1.06) | 64.72 (1.17)* | 0.91 (0.01)* | 0.71 (0.01) | |
| GA | 130 | 6.20 (0.60)* | 24.59 (1.07)* | 69.21 (1.17)*† | 0.94 (0.01)* | 0.74 (0.01)* | ||
| GG | 29 | 8.49 (1.27) | 31.69 (2.26)* | 59.82 (2.48)† | 0.92 (0.01) | 0.65 (0.03)* | ||
| P-value | .005 | .018 | .001 | .005 | .007 | |||
| rs4816333 | CC | 107 | 7.32 (0.67) | 26.76 (1.19) | 65.92 (1.31) | 0.93 (0.01) | 0.71 (0.01) | |
| CG | 132 | 7.15 (0.60) | 25.53 (1.07) | 67.33 (1.19) | 0.93 (0.01) | 0.72 (0.01) | ||
| GG | 50 | 9.81 (0.98) | 26.08 (1.74) | 64.11 (1.93) | 0.90 (0.01) | 0.71 (0.02) | ||
| P-value | .055 | .744 | .349 | .055 | .677 | |||
| rs7282280 | CC | 174 | 7.94 (0.53) | 26.21 (0.93) | 65.86 (1.03) | 0.92 (0.01) | 0.72 (0.01) | |
| CT | 101 | 7.17 (0.70) | 25.59 (1.23) | 67.25 (1.37) | 0.93 (0.01) | 0.72 (0.01) | ||
| TT | 14 | 8.03 (1.88) | 28.11 (3.32) | 63.87 (3.68) | 0.92 (0.02) | 0.69 (0.04) | ||
| P-value | .668 | .762 | .584 | .668 | .733 | |||
| rs7282257 | TT | 68 | 9.62 (0.84)* | 24.69 (1.49) | 65.69 (1.66) | 0.90 (0.01)* | 0.73 (0.02) | |
| TA | 143 | 7.26 (0.57) | 26.66 (1.03) | 66.07 (1.14) | 0.93 (0.01) | 0.71 (0.01) | ||
| AA | 78 | 6.73 (0.78)* | 26.23 (1.39) | 67.04 (1.55) | 0.93 (0.01)* | 0.72 (0.02) | ||
| P-value | .026 | .548 | .820 | .026 | .716 | |||
| rs2065266 | CC | 144 | 8.85 (0.57)* | 25.75 (1.02) | 65.40 (1.13) | 0.91 (0.01)* | 0.72 (0.01) | |
| CT | 120 | 6.16 (0.62)* | 26.09 (1.12) | 67.76 (1.24) | 0.94 (0.01)* | 0.72 (0.01) | ||
| TT | 25 | 8.20 (1.38) | 27.94 (2.47) | 63.86 (2.74) | 0.92 (0.01) | 0.70 (0.03) | ||
| P-value | .006 | .716 | .250 | .006 | .692 | |||
| rs2738966 | GG | 67 | 9.49 (0.84)* | 24.43 (1.50) | 66.08 (1.67) | 0.91 (0.01)* | 0.73 (0.02) | |
| GA | 147 | 7.44 (0.57) | 27.16 (1.01) | 65.40 (1.12) | 0.93 (0.01) | 0.71 (0.01) | ||
| AA | 75 | 6.52 (0.80)* | 25.43 (1.42) | 68.05 (1.58) | 0.94 (0.01)* | 0.73 (0.02) | ||
| P-value | .033 | .280 | .391 | .033 | .316 | |||
| rs2248501 | GG | 75 | 6.52 (0.80)* | 25.43 (1.42) | 68.05 (1.58) | 0.94 (0.01)* | 0.73 (0.02) | |
| GT | 147 | 7.44 (0.57) | 27.16 (1.01) | 65.40 (1.12) | 0.93 (0.01) | 0.71 (0.01) | ||
| TT | 67 | 9.49 (0.84)* | 24.43 (1.50) | 66.08 (1.67) | 0.91 (0.01)* | 0.73 (0.02) | ||
| P-value | .033 | .280 | .391 | .033 | .316 | |||
| As3MT | rs7085104 | AA | 80 | 8.09 (0.78) | 24.86 (1.38) | 67.04 (1.54) | 0.92 (0.01) | 0.73 (0.02) |
| AG | 142 | 6.96 (0.58) | 27.68 (1.03) | 65.36 (1.15) | 0.93 (0.01) | 0.70 (0.01) | ||
| GG | 67 | 8.69 (0.87) | 24.14 (1.53) | 67.18 (1.71) | 0.91 (0.01) | 0.73 (0.02) | ||
| P-value | .208 | .091 | .559 | .208 | .184 | |||
| rs3740400 | CC | 84 | 7.75 (0.78) | 24.96 (1.36) | 67.30 (1.51) | 0.92 (0.01) | 0.73 (0.02) | |
| CA | 146 | 7.44 (0.58) | 27.83 (1.01) | 64.73 (1.12) | 0.93 (0.01) | 0.70 (0.01) | ||
| AA | 56 | 8.28 (0.94) | 23.50 (1.64) | 68.23 (1.82) | 0.92 (0.01) | 0.74 (0.02) | ||
| P-value | .746 | .046 | .175 | .746 | .064 | |||
| rs3740393 | CC | 15 | 7.97 (1.79) | 24.82 (3.19) | 67.21 (3.52) | 0.92 (0.02) | 0.73 (0.04) | |
| CG | 117 | 6.68 (0.64) | 25.05 (1.14) | 68.28 (1.26) | 0.93 (0.01) | 0.73 (0.01) | ||
| GG | 157 | 8.39 (0.55) | 26.97 (0.98) | 64.64 (1.09) | 0.92 (0.01) | 0.71 (0.01) | ||
| P-value | .132 | .414 | .092 | .132 | .286 | |||
| rs3740390 | GG | 158 | 8.41 (0.55) | 26.93 (0.98) | 64.67 (1.08) | 0.92 (0.01) | 0.71 (0.01) | |
| GA | 116 | 6.64 (0.64) | 25.09 (1.14) | 68.28 (1.26) | 0.93 (0.01) | 0.73 (0.01) | ||
| AA | 15 | 7.97 (1.79) | 24.83 (3.19) | 67.21 (3.52) | 0.92 (0.02) | 0.73 (0.04) | ||
| P-value | .116 | .441 | .095 | .116 | .305 | |||
| rs1046778 | TT | 83 | 8.70 (0.76) | 26.57 (1.36) | 64.74 (1.50) | 0.91 (0.01) | 0.71 (0.02) | |
| TC | 158 | 7.44 (0.55) | 25.92 (0.98) | 66.64 (1.08) | 0.93 (0.01) | 0.72 (0.01) | ||
| CC | 48 | 6.67 (1.00) | 25.78 (1.78) | 67.55 (1.98) | 0.93 (0.01) | 0.72 (0.02) | ||
| P-value | .230 | .913 | .458 | .230 | .806 |
a
The genotype of ancestral allele homozygote in each SNP was denoted first.
b
Mean (Standard Error). ANCOVA were used to adjust for potential confounding variablesat the following values: Gender = 1.4014, Age = 50.529, BMI = 24.616, Smoker = 0.3668, Drinker = 0.3080.
c
Comparison was done among any 2 groups, and those marked with same symbols (*,†) were significantly different (P < .05).