TABLE 4.
Influence of N6AMT1 and As3MT haplotypes on fractions of arsenic metabolites and methylation capacity indexes.
| Gene | Haplotype | Frequency (%) | Copies | n | % iAs | % MMA | % DMA | PMI | SMI |
|---|---|---|---|---|---|---|---|---|---|
| N6AMT1 | Haplotype 1_GAGCTC | 31.8 | 0 | 134 | 7.33 (0.60)a | 26.55 (1.06) | 66.12 (1.18) | 0.93 (0.01) | 0.71 (0.01) |
| 1/2 | 125/30 | 7.97 (0.56) | 25.67 (0.98) | 66.36 (1.09) | 0.92 (0.01) | 0.72 (0.01) | |||
| P-value | .435 | .544 | .882 | .435 | .574 | ||||
| Haplotype 2_GGCCAT | 27.2 | 0 | 147 | 8.83 (0.56) | 26.49 (1.03) | 65.49 (1.12) | 0.91 (0.01) | 0.72 (0.01) | |
| 1/2 | 122/20 | 6.48 (0.57) | 25.69 (1.01) | 67.03 (1.14) | 0.94 (0.01) | 0.72 (0.01) | |||
| P-value | .004 | .579 | .336 | .004 | .925 | ||||
| Haplotype3_CACCTC | 11.3 | 0 | 228 | 7.41 (0.46) | 26.06 (0.82) | 66.54 (0.90) | 0.93 (0.01) | 0.72 (0.01) | |
| 1/2 | 57/4 | 8.67 (0.90) | 26.17 (1.59) | 65.16 (1.77) | 0.91 (0.01) | 0.71 (0.02) | |||
| P-value | .215 | .948 | .490 | .215 | .842 | ||||
| Haplotype 4_CACTAC | 10.0 | 0 | 233 | 7.99 (0.45) | 26.07 (0.80) | 65.94 (0.89) | 0.92 (0.01) | 0.72 (0.01) | |
| 1/2 | 54/2 | 6.35 (0.92) | 26.12 (1.64) | 67.54 (1.82) | 0.94 (0.01) | 0.72 (0.02) | |||
| P-value | .111 | .980 | .430 | .111 | .913 | ||||
| Haplotype 5_GAGTAC | 7.5 | 0 | 251 | 7.62 (0.44) | 25.95 (0.77) | 66.43 (0.86) | 0.92 (0.01) | 0.72 (0.01) | |
| 1/2 | 36/2 | 8.03 (1.13) | 26.92 (2.00) | 65.06 (2.22) | 0.92 (0.01) | 0.71 (0.02) | |||
| P-value | .739 | .654 | .566 | .739 | .570 | ||||
| As3MT | Haplotype 1_AAGT | 44.5 | 0 | 85 | 7.72 (0.77) | 24.92 (1.36) | 67.37 (1.51) | 0.92 (0.01) | 0.73 (0.02) |
| 1/2 | 150/54 | 7.66 (0.49) | 26.57 (0.87) | 65.78 (0.96) | 0.92 (0.01) | 0.71 (0.01) | |||
| P-value | .949 | .315 | .383 | .949 | .348 | ||||
| Haplotype 2_GCAC | 25.2 | 0 | 158 | 8.41 (0.55) | 26.93 (0.98) | 64.66 (1.08) | 0.92 (0.01) | 0.71 (0.01) | |
| 1/2 | 116/15 | 6.79 (0.61) | 25.06 (1.08) | 68.15 (1.19) | 0.93 (0.01) | 0.73 (0.01) | |||
| P-value | .051 | .201 | .031 | .051 | .123 | ||||
| Haplotype 3_GCGT | 11.5 | 0 | 227 | 7.25 (0.46) | 25.92 (0.82) | 66.83 (0.91) | 0.93 (0.01) | 0.72 (0.01) | |
| 1/2 | 58/4 | 9.21 (0.89) | 26.67 (1.59) | 64.12 (1.76) | 0.91 (0.01) | 0.71 (0.02) | |||
| P-value | .054 | .680 | .177 | .054 | .456 | ||||
| Haplotype 4_GCGC | 11.0 | 0 | 229 | 7.45 (0.46) | 26.07 (0.81) | 66.49 (0.90) | 0.93 (0.01) | 0.72 (0.01) | |
| 1/2 | 56/4 | 8.54 (0.89) | 26.12 (1.58) | 65.33 (1.76) | 0.92 (0.01) | 0.71 (0.02) | |||
| P-value | .275 | .975 | .560 | .275 | .865 | ||||
| Haplotype 5_ACGC | 7.1 | 0 | 249 | 7.92 (0.44) | 25.79 (0.78) | 66.30 (0.86) | 0.92 (0.01) | 0.72 (0.01) | |
| 1/2 | 39/1 | 6.16 (1.10) | 27.92 (1.94) | 65.92 (2.16) | 0.94 (0.01) | 0.70 (0.02) | |||
| P-value | .137 | .307 | .870 | .137 | .439 |
a
Mean (Standard Error). ANCOVA were used to adjust for potential confounding variables at the following values: Gender = 1.4014, Age = 50.529, BMI = 24.616, Smoker = 0.3668, Drinker = 0.3080.