FIG. 7.

Adiponectin secretion results. Secretion of adiponectin into the assay medium was assessed in concentration-response format for rosiglitazone (A) and tributyltin (B). Values are mean ± SEM of 3 independent replicates. The performance of control values from all plates run in the assay (n = 22) demonstrate concentration (C) and dynamic range (D) of the assay. Each box and whisker plot displays the median, first and third quartiles (boxes), and the 2.5–97.5 percentile (whiskers). Results from the chemicals screened in the adiponectin assay were scored for significance and plotted as rank-ordered (left-to-right) maximum fold-change observed for any concentration point in the viable range of each chemical (D). The corresponding AC₅₀ values and TCC are plotted for each hit identified (E).