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. 2016 Sep 23;155(1):85–100. doi: 10.1093/toxsci/kfw186

TABLE 2.

Classification of Hit Frequency for Chemicals Run in All Adipogenesis Assays

Hit Classification
Chemical CASRN Total AUC Median AC50 (μM) # Hits Strong (6–8) Moderate (3–5) Weak (1–2) Inactive (0)
Rosiglitazone 122320-73-4 647.05 0.0610 8 *
Tributyltin Chloride 1461-22-9 149.82 0.0100 7 *
Lactofen 77501-63-4 140.61 29.21 8 *
Fentin 76-87-9 125.23 0.0049 8 *
Diclofop-methyl 51338-27-3 123.72 56.47 8 *
MEHP 4376-20-9 120.78 52.46 8 *
Halosulfuron-methyl 100784-20-1 98.01 40.65 6 *
Fludioxonil 131341-86-1 97.36 18.77 8 *
Cyfluthrin 68359-37-5 71.80 37.38 4 *
Flufenacet 142459-58-3 56.49 51.87 5 *
Isoxaflutole 141112-29-0 51.21 42.09 4 *
Triflumizole 68694-11-1 45.82 8.46 6 *
Quinoxyfen 124495-18-7 39.88 21.76 5 *
Piperonyl butoxide 51-03-6 31.82 63.81 3 *
Pyraclostrobin 175013-18-0 31.80 8.41 4 *
Tebufenozide 112410-23-8 24.33 23.27 4 *
Isazofos 42509-80-8 14.50 35.87 2 *
Triallate 2303-17-5 13.25 67.51 2 *
S-Bioallethrin 28434-00-6 10.38 26.18 2 *
Fenpyroximate 111812-58-9 10.31 11.00 1 *
Boscalid 188425-85-6 9.74 17.14 2 *
Pyridaben 96489-71-3 8.75 6.10 1 *
Esfenvalerate 66230-04-4 8.47 39.74 1 *
Dithiopyr 97886-45-8 8.33 45.44 1 *
Bisphenol A 80-05-7 6.99 77.66 1 *
Tebufenpyrad 119168-77-3 6.74 16.10 1 *
Prochloraz 67747-09-5 6.08 24.49 1 *
Indoxacarb 173584-44-6 5.30 13.72 1 *
Asulam 3337-71-1 0.00 NA 0 *

Summary values for chemical efficacy (AUC) and potency (AC50) are shown for the 26 chemical hits identified from the adipogenesis screen, as well as rosiglitazone and tributyltin positive controls (PC), and asulam negative control (NC). Hit frequency is reported across the 8 orthologous adipocyte endpoints, and are stratified into strong (6–8), moderate (3–5), weak (1–2), and inactive (0) hits.