FIG. 1.

Binding of [³H]Ry to the RyR1 in the presence of PCB 202 in comparison to PCB 95, 194, and PCB 197 to demonstrate the importance of ortho, meta, and para-chlorine substitutions. Specific binding is shown relative to DMSO control (100%). Congeners were placed in different panel to aid visualization. Concentration response curves were assessed using nonlinear regression. Numbers represent Mean ± SEM; from 2 protein preparations (n ≥ 2) where each treatment was run in triplicate for each protein preparation.