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. 2016 Oct 3;155(1):248–257. doi: 10.1093/toxsci/kfw198

FIG. 4.

FIG. 4

Genes differentially expressed following in vitro ECIG exposure are enriched among genes differentially expressed in airway epithelial samples from ECIG users. (Top) Enrichment plot showing the rank of genes with increased expression in vitro in the list of genes ranked from most increased to most decreased by ECIG use in vivo. Genes upregulated with ECIG exposure in vitro are significantly enriched among the genes most induced in the airway of former smokers using ECIGs (n = 16) (q < .01). (Bottom) Enrichment plot showing the rank of genes with decreased expression in vitro in the list of genes ranked from most increased to most decreased by ECIG use in vivo. Genes downregulated with ECIG exposure in vitro are significantly enriched among the genes most downregulated in the airway of former smokers using ECIGs (n = 16) (q < .01).