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. 2016 Jun 30;7(29):44927–44940. doi: 10.18632/oncotarget.10342

Figure 4. Fetal MIP-βIRKO islets have enhanced replication and pro-survival signaling pathway activity.

Figure 4

Western blot analyses of phospho-S473 Akt (P-Akt) and total Akt (T-Akt) (A., n = 4), phospho-S15 p53 (P-p53) and total p53 (T-p53) (B., n = 3-4), and Igf-2 protein level (C., n = 5-13) in fetal pancreata from MIP-βIRKO and control mice. Representative blotting images are shown. White bar, control group; black bar, MIP-βIRKO group. Data are expressed as means ± SEM. *p < 0.05, **p < 0.01 vs. controls. Representative immunohistochemical images for D. Igf-2, E. Igf-1, and F. Igf-1r staining of MIP-βIRKO and control pancreatic sections. Nuclei were counterstained with hematoxylin. Scale bar: 50 μm.