Table 1. Sensitivity of human carcinoma cell lines to p53 SMWC.
| Cell lines | CP-31398 | PRIMA-1 | ||
|---|---|---|---|---|
| IC50 (μM) | The concentration of maximum toxicity (μM) | IC50 (μM) | The concentration of maximum toxicity (μM) | |
| SUM149 | 30 | 80 - IC85* | 50 | 100-200 - IC80** |
| MDA-MB-231 | 20 | 80 - IC85* | 75 | 200 - IC80* |
| Ishikawa | 30 | 110 - IC80* | 60 | 100-200 - IC80** |
| AN 3CA | 28 | 55 - IC80* | 50 | 100-200 - IC80** |
| HEC-1-B | 28 | 55-110 - IC80** | 40 | 100-200 - IC70** |
| Panc02 | 40 | 55 - IC85* | 70 | 200 - IC90* |
| PANC-1 | 55 | 110 - IC85* | 35 | 100-200 - IC80** |
The sensitivity of a panel comprised of two human breast, three endometrial, and two pancreas carcinoma cell lines to CP-31398 and PRIMA-1. The IC50 and concentration of maximum toxicity for each carcinoma cell line were determined in standard MTT assays.
*
indicates the concentration of maximum cytotoxicity following 24 h incubation with p53 SMWC.
**
indicates the level of cytotoxicity remained the same in this concentration range.