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. 2016 Jun 7;7(29):45199–45213. doi: 10.18632/oncotarget.9900

Figure 6. High level of miR-20a-5p was correlated with the metastasis and predicted poor prognosis in colorectal cancer patients.

Figure 6

(A) The expression of miR-20a-5p mRNA in 544 patients normal and paired tumor tissues through qRT-PCR (P < 0.001). (B) The expression of miR-20a-5p mRNA in metastasis and non-metastasis tumor tissues. (C) The expression of Smad4 protein in tissues through IHC staining method: C1 normal tissue with low miR-20a-5p and Smad4 strong staining; C2 non-metastasis tumor tissue with high miR-20a-5p and Smad4 moderated staining, C3 metastatic tumor tissue with high miR-20a-5p and Smad4 weak staining. (D) Disease free survival (DFS) and (E) overall survival (OS) rates in 544 patients by Kaplan–Meier analysis with log-rank test (**P < 0.001). (F and G) overall survival (OS) rates in patients with tumor relapse (P = 0.003) and without tumor relapse patients (P = 0.547) by Kaplan–Meier analysis with log-rank test.