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. 2016 May 19;7(29):45263–45274. doi: 10.18632/oncotarget.9481

Figure 4. MLN4924 arrests cell cycle in the G2 phase and induces senescence in OS cell lines.

Figure 4

a. SJSA-1 and MG-63 OS cells were treated with MLN4924 for 48 h, stained with PI, and examined with flow cytometry assays. (left panels) Representative plots of the cell cycle phases from three independent experiments are shown for SJSA-1 and MG-63 cells treated with 0.04 μM or 1 μM MLN4924. (right panels) The fractions of SJSA-1 an MG-63 cells in each phase of the cell cycle are shown. b. SJSA-1 and MG-63 OS cells were treated with 1 μM MLN4924 for 48 h and senescence was examined by β-galactosidase staining.