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. 2016 May 26;7(29):45331–45351. doi: 10.18632/oncotarget.9644

Figure 9. Effects of RP and CQ on autophagy in Aldo-induced rats.

Figure 9

A. Representative electron micrographs showing autophagic vacuoles in podocytes. The red arrow indicates autophagosomes, and the yellow arrow indicates autolysosomes. Scale bar=2 μm. B. Graphical presentation indicates the abundance of autophagic vacuoles in various groups, as indicated. C. Immunohistochemical staining for LC3 in rat kidney tissue from various groups, as indicated. Scale bar=50 μm. D. Western blot analysis revealed the expression of LC3II/LC3I, p62, and β-actin proteins after various treatments in rats, as indicated. E. Graphical presentation shows the relative abundance levels of LC3II/LC3I and p62 after normalization with β-actin. Results (means±SEM) of 3 series of experiments. #P<0.05 vs. normal control, *P<0.05 vs. Aldo alone.