Table 2. GO-Terms enrichment analysis.
Gene enrichment analysis in 2cPE treated primary B-CLL cells | ||||||
---|---|---|---|---|---|---|
GO-Term | Count | % | p Value | Benjamini | FDR | Fold Enr |
GO:0006986~response to unfolded protein | 13 | 8,33 | 1,66E-12 | 2,67E-09 | 2,78E-09 | 19,82 |
GO:0051789~response to protein stimulus | 13 | 8,33 | 3,90E-07 | 1,96E-07 | 4,08E-07 | 13,15 |
GO:0050865~regulation of cell activation | 14 | 8,97 | 7,16E-09 | 3,84E-06 | 1,20E-05 | 8,66 |
GO:0010033~response to organic substance | 25 | 16,02 | 3,11E-08 | 1,25E-05 | 5,21E-05 | 3,75 |
GO:0006457~protein folding | 13 | 8,33 | 7,73E-08 | 1,75E-05 | 0,00013 | 7,94 |
GO:0042981~regulation of apoptosis | 25 | 16,02 | 2,38E-07 | 4,80E-05 | 0,0004 | 3,37 |
Gene enrichment analysis in Bortezomib treated primary B-CLL cells | ||||||
GO-Term | Count | % | p Value | Benjamini | FDR | Fold Enr |
GO:0000502~proteasome complex | 14 | 15,73 | 4,31E-18 | 5,26E-16 | 4,97E-15 | 42,52 |
GO:0051351~positive regulation of ligase activity | 15 | 16,85 | 1,35E-18 | 1,16E-15 | 2,09E-15 | 37,56 |
GO:0043161~proteasomal protein catabolic process | 15 | 16,85 | 1,91E-16 | 1,91E-14 | 3,44E-13 | 26,88 |