Skip to main content
. 2016 Jun 14;7(29):45562–45574. doi: 10.18632/oncotarget.10037

Figure 4. CHMFL-074's effect on BCR-ABL mediated signaling pathway, cell cycle progression and apoptosis.

Figure 4

(A) CHMFL-074's effect on BCR-ABL(p210) Y245 phosphorylation site in the native and mutants of p210 transformed BaF3 isogenic cell lines. (B) CHMFL-074's effect on BCR-ABL mediated signaling pathways in the K562, KU812 and MEG-01 cells at different concentrations at 2 h. (C) CHMFL-074's effect on the cell cycle progression in the K562 (24 h), KU812 (12 h) and MEG-01(24 h) cells at different concentrations. (D) CHMFL-074's effect on the apoptosis induction at different concentrations in K562, KU812 and MEG-01 cells at 24 h.