Table 1. Results of multivariate cox-proportional hazard analysis of 4-miRNA risk score, age, sex and MGMT promoter methylation status.

Cohort	Model	Hazard ratios of parameters	Confidence intervals of hazard ratios	p-values of contributions of parameters to model	p-value of model
Discovery	4-miRNA risk-score	3.8	1.47-9.75	0.00574	0.00434
	MGMTmeth	0.9	0.39-2	0.7637	0.76298
	4-miRNA risk-score+MGMTmeth	3.8,0.9	1.48-9.81/0.38-1.93	0.00558,0.70124	0.0159
	Sex	1.7	0.72-3.86	0.22874	0.22151
	4-miRNA risk-score+Sex	3.6,1.3	1.36-9.32/0.57-3.16	0.00982,0.50574	0.01367
	Age	1	1-1.07	0.05469	0.05267
	4-miRNA risk-score+Age	3.5,1	1.35-9.12/0.99-1.07	0.00979,0.10002	0.00439
	4-miRNA risk-score+MGMTmeth+Sex+Age	3.3,0.9,1,1.4	1.23-8.62/0.38-2.15/0.99-1.07/0.59-3.44	0.01765,0.82414,0.11408,0.43099	0.02158
Validation	4-miRNA risk-score	2.4	1.03-5.69	0.04207	0.04247
	MGMTmeth_1	0.5	0.18-1.27	0.13798	0.12236
	MGMTmeth_2	0.5	0.21-1.32	0.16924	0.15812
	4-miRNA risk-score+MGMTmeth_1	3.1,0.4	1.24-7.73/0.12-1.01	0.0156,0.05204	0.01532
	4-miRNA risk-score+MGMTmeth_2	2.2,0.6	0.93-5.28/0.24-1.55	0.07096,0.29498	0.07214
	Sex	1.5	0.57-3.8	0.41996	0.41121
	4-miRNA risk-score+Sex	1	1.36-0.9-9.31-7.64	0.00947,0.07811	0.02402
	Age	1	0.94-1.04	0.63117	0.63333
	4-miRNA risk-score+Age	0	1.09-0.93-6.25-1.03	0.03098,0.37596	0.08763
	4-miRNA risk-score+MGMTmeth_1+Sex+Age	4.1,0.5,2.1,1	1.44-11.49/0.16-1.79	0.008,0.30791, 0.24802,0.37623	0.03941
	4-miRNA risk-score+MGMTmeth_2+Sex+Age	4.5,1,3,1	1.41-14.67/0.34-3.09	0.01139,0.95454,0.08428,0.22869	0.06184