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. 2016 Jun 14;7(29):45959–45975. doi: 10.18632/oncotarget.10009

Figure 3. Short form RON induces oncogenic phenotypes and has transforming capacity.

Figure 3

A. HPDE cell line expressing the sfRON-eGFP fusion protein showed no change in cell morphology but expressed high levels of the protein. B. The sfRONe protein is expressed in 3 different cell lines at similar levels. The protein is constitutively active in each cell line but with different levels of phosphorylation. C. MSP ligand activates full length RON but not short form RON. D. Signaling downstream of sfRON activates the MAPK and AKT pathway. E. Short form RON expression in the HPDE cell line increases cell motility more than full length RON activation with MSP alone.