Table 1. Selectivity of LDC047896 for RON on biochemical and cellular levels in comparison to BMS777607.
Biochemical RON kinase assay IC50[nM] | Biochemical cMET kinase assay IC50[nM] | Cellular RON inhibition IC50[nM] | Cellular cMET inhibition IC50[nM] | |
---|---|---|---|---|
LDC047896 | 21 | 74 | 1.6 | 2000 |
BMS777607 | 12 | 1.4 | 14 | 150 |