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. 2016 Jun 14;7(29):46028–46041. doi: 10.18632/oncotarget.10016

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Copyright: © 2016 Atashrazm et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The APL bearing mice were treated with fucoidan, ATO and ATRA. A. The Kaplan-Meier survival curve for mice treated with fucoidan, ATO and their combination compared to the control group for over 28 days of treatment. Mice were sacrificed when tumor volume reached 1000mm³ B. Tumor volume doubling time in mice treated with fucoidan, ATO and their combination compared to the control group (n=7/group) (mean ± SD). C. The Kaplan-Meier survival curve for mice treated with fucoidan, ATRA and their combination compared to the control group for over 28 days of treatment. D. Tumor volume doubling time indicative of tumor aggressiveness in mice treated with fucoidan, ATRA and their combination compared to the control group (n=8/group) (mean ± SD). Statistical significance was determined by ANOVA, followed by Tukey's multiple comparison test (**: p<0.01, *: p<0.05). The inserted ‘table’ represents the median survival and the statistical significance is compared to the control.