Table 1. Cell cycle phases' distribution in NB4 cells treated with fucoidan, ATO or in combination.
Sub G0/G1 | G0/G1 | S | Mitosis | ||
---|---|---|---|---|---|
ATO 0.25 μM | Control | 1.93 ± 0.3 | 42.46 ± 1.39 | 22.34 ± 0.06 | 31.67 ± 1.34 |
Fucoidan | 18.34 ± 1.75 | 28.66 ± 1.42 | 22.38 ± 2.7 | 29.18 ± 3.38 | |
ATO | 2.73 ± 1.08 | 45.10 ± 0.54 | 20.22 ± 0.41 | 30.39 ± 0.87 | |
Combination | 20.69 ± 1.54 | 31.30 ± 0.09 | 25.8 ± 2.68 | 19.44 ± 2.04 | |
ATO 0.5 μM | Control | 1.93 ± 0.3 | 42.46 ± 1.39 | 22.34 ± 0.06 | 31.67 ± 1.34 |
Fucoidan | 18.34 ± 1.75 | 28.66 ± 1.42 | 22.38 ± 2.7 | 29.18 ± 3.38 | |
ATO | 2.39 ± 1.08 | 46.10 ± 0.54 | 20.22 ± 0.41 | 29.39 ± 0.87 | |
Combination | 25.57 ± 0.86 | 38.42 ± 1.38 | 15.20 ± 0.34 | 18.14 ± 1.66 | |
ATO 1.0 μM | Control | 1.93 ± 0.3 | 42.46 ± 1.39 | 22.34 ± 0.06 | 31.67 ± 1.34 |
Fucoidan | 18.34 ± 1.75 | 28.66 ± 1.42 | 22.38 ± 2.7 | 29.18 ± 3.38 | |
ATO | 15.13 ± 0.4 | 39.81 ± 3.82 | 16.56 ± 0.8 | 25.50 ± 2.11 | |
Combination | 74.51 ± 2.26 | 7.29 ± 1.36 | 9.28 ± 2.28 | 6.76 ± 0.7 |
NB4 cells were treated with with low and therapeutic doses of ATO with or without fucoidan (20 μg/ml) and cell cycle was analyzed after 48 hours. Data represents Mean±SEM of three replicates.