Table 2. Cell cycle phases' distribution in NB4 cells treated with fucoidan, ATRA, ATO or in combinations.
G0/G1 | S | Mitosis | ||
---|---|---|---|---|
Agents alone | Control | 60.64 ± 0.41 | 20.65 ± 1.1 | 18.07 ± 0.89 |
Fucoidan | 65.1 ± 1.54 | 20.77 ± 1.44 | 13.3 ± 0.1 | |
ATRA | 76.01 ± 1.05 | 8.53 ± 1.0 | 15.12 ± 0.08 | |
ATO | 64.4 ± 0.95 | 18.29 ± 1.29 | 16.64 ± 0.31 | |
Combination | ATRA+fucoidan | 84.28 ± 1.81 | 5.24 ± 0.21 | 10.24 ± 1.61 |
ATO+fucoidan | 66.01 ± 2.95 | 21.94 ± 1.77 | 11.38 ± 1.02 | |
ATRA + ATO | 82.44 ± 0.53 | 6.78 ± 0.06 | 10.58 ± 0.65 | |
ATRA+ATO+fucoidan | 89.86 ± 1.11 | 4.42 ± 0.94 | 5.41 ± 0.16 |
NB4 cells were treated with ATRA (0.5 μM) and ATO (0.5 μM) with or without fucoidan (5 μg/ml) and cell cycle was analyzed after 5 days. Data represents Mean±SEM of three replicates.