Table 1. Clinicopathological factors and microbiota in CRC patients.

Characteristic	BH	BL	P value	FAH	FAL	P value	FUH	FUL	P value
Age			0.224			0.761			0.128
<60	32	40		35	37		31	41
>=60	58	50		55	53		59	49
Gender			0.543			0.761			0.361
Male	56	52		55	53		51	57
Female	34	38		35	37		39	33
Location			0.443			0.646			0.878
Colon	32	37		33	36		35	34
Rectum	58	53		57	54		55	56
Tumor size			0.168			0.443			0.092
<5cm	51	60		53	58		50	61
>=5cm	39	30		37	32		40	29
CEA			0.124			0.356			0.758
Normal	51	61		53	59		55	57
Elevated	39	29		37	31		35	33
Grade of differentiation			0.092			0.736			0.312
Well	61	71		65	67		63	69
Poor	29	19		25	23		27	21
Depth of invasion			0.083			0.015*			0.015*
T1 and T2	17	27		15	29		15	29
T3 and T4	73	63		75	61		75	61
Lymph node metastasis			0.036			0.901			0.011*
Negative	43	57		58	53		42	59
Positive	47	33		42	37		48	31
Remote Metastasis			1			0.278			0.718
Negative	86	86		84	88		85	87
Positive	4	4		6	2		5	3
TNM stage			0.052			0.296			0.101
I and II	41	54		44	51		42	53
III and IV	49	36		46	39		48	37

Bonferroni-correction: α=0.017

^*statistically significant P <0.017

Abbreviation: BH: B. fragilis high, BL: B. fragilis low, FAH: F. prausnitzii high, FAL: F. prausnitzii low, FUH: F. nucleatum high, FUL: F. nucleatum low.