Figure 4. CQ-treatment significantly inhibits cHL growth in-vivo.
1×105 cells of BL cell line BL2 A. and 1×106 cells of cHL cell line L428 B. were transplanted subcutaneously into the flanks of highly immunodeficient NSG mice (10 animals per cell line). After successful growth of xenograft tumors, recipient animals were divided into two cohorts for each cell line. Animals were either treated by daily intraperitoneal injections of 60 mg/kg CQ in PBS or with PBS only, as a control. Statistical analysis was performed by two-way ANOVA test. The statistical significance for the comparison of PBS and CQ-treated animals of the L428 group is indicated by the P-value shown in the graph.