Table 3. Multivariate Cox proportional hazard model for assessing outcome-related factors.
Variable | BCSS | OS | ||||
---|---|---|---|---|---|---|
HR | 95% CI | Pc | HR | 95% CI | Pc | |
Age (years) | ||||||
≥50 | 1 | 1 | ||||
<50 | 0.974 | 0.778-1.218 | 0.815 | 0.773 | 0.643-0.929 | 0.006 |
Race | 0.144 | 0.029 | ||||
White | 1 | 1 | ||||
Black | 1.051 | 0.811-1.362 | 0.709 | 1.047 | 0.855-1.283 | 0.655 |
Othera | 0.606 | 0.359-1.023 | 0.061 | 0.569 | 0.370-0.876 | 0.010 |
Marital status | ||||||
Married | 1 | 1 | ||||
Not marriedb | 1.144 | 0.915-1.427 | 0.234 | 1.269 | 1.067-1.508 | 0.007 |
Grade | ||||||
III | 1 | 1 | ||||
I/II | 0.697 | 0.490-0.994 | 0.046 | 0.882 | 0.690-1.128 | 0.316 |
Tumor size | <0.001 | <0.001 | ||||
T1 | 1 | 1 | ||||
T2 | 1.884 | 1.427-2.487 | <0.001 | 1.644 | 1.338-2.019 | <0.001 |
T3 | 3.735 | 2.653-5.259 | <0.001 | 3.032 | 2.322-3.959 | <0.001 |
Lymph node status | <0.001 | <0.001 | ||||
N0 | 1 | 1 | ||||
N1 | 2.836 | 2.182-3.686 | <0.001 | 2.024 | 1.650-2.482 | <0.001 |
N2 | 3.311 | 2.260-4.850 | <0.001 | 2.940 | 2.199-3.931 | <0.001 |
N3 | 7.725 | 5.464-10.922 | <0.001 | 5.599 | 4.228-7.415 | <0.001 |
Type of surgery | <0.001 | <0.001 | ||||
Breast-conserving surgery | 1 | 1 | ||||
Mastectomy | 1.167 | 0.902-1.510 | 0.240 | 1.208 | 0.986-1.480 | 0.069 |
None | 2.810 | 1.800-4.387 | <0.001 | 3.067 | 2.179-4.317 | <0.001 |
Radiation therapy | ||||||
No | 1 | 1 | ||||
Yes | 0.659 | 0.520-0.835 | 0.001 | 0.582 | 0.481-0.704 | <0.001 |
Abbreviation: CI, confidence interval.
Other includes American Indian/native Alaskan and Asian/Pacific Islander.
Not married includes divorced, separated, single (never married), unmarried or domestic partner and widowed.
P values were adjusted using a multivariate Cox proportional hazard regression model including all factors, as categorized in Table 3, and bold type indicates significance.