Table 3. FGFR2 translocations in ICC.
Study | No. of patients (n) | No. of patients with FGFR2 translocation (n, %) | Type of FGFR2 Translocations | Method |
---|---|---|---|---|
Wu et al. [59] | 2 | 2 (100%) | FGFR2-BICC1 | RNA, exome sequencing |
Borad et al. [30] | 6 | 3 (50%) |
FGFR2-TACC3 FGFR2-BICC1 FGFR2-MGEA5 |
Genome-wide and whole transcriptome sequencing |
Graham et al. [29] | 96 | 12 (13%) | NR | Fluorescence in situ hybridization |
Arai et al. [28] | 66 | 9 (13.6%) |
FGFR2-AHCYL1 FGFR2-BICC1 |
Whole transcriptome sequencing |
Ross et al.[17] | 28 | 3 (10.7%) |
FGFR2-KIAA1598 FGFR2-BICC1 FGFR2-TACC3 |
Next generation sequencing |
Sia et al. [31] | 107 | 48 (45%) |
FGFR2-PPHLN1 FGFR2-BICC1 |
RNA, exome sequencing |
Nakamura et al. [60] | 109 | 6 (5.5%) |
FGFR2-KCTD1 FGFR2-TXLNA FGFR2-BICC1(Type 2) |
Exome sequencing |
Abbreviations: NR, Not reported