Table 2.
Mean FA per Group at Baseline and at Follow-up
| Brain Region | Mean FA | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Controls | Siblings | Patients | |||||||
| T0 | T1 | Δ | T0 | T1 | Δ | T0 | T1 | Δ | |
| Genu of corpus callosum | .7570 | .7557 | −.0012 | .7551 | .7515 | −.0036 | .7466 | .7446 | −.0020 |
| Body of corpus callosum | .7214 | .7216 | .0003 | .7175 | .7155 | −.0020 | .7035 | .7007 | −.0028 |
| Splenium of corpus callosum | .7877 | .7915 | .0037 | .7891 | .7873 | −.0018 | .7880 | .7897 | .0017 |
| Forceps major | .7004 | .7042 | .0038* | .6974 | .6956 | −.0018 | .6904 | .6896 | −.0009 |
| Forceps minor | .5850 | .5848 | −.0002 | .5827 | .5800 | −.0026 | .5785 | .5779 | −.0006 |
| Fornix (column and body) | .5278 | .5199 | −.0078 | .5305 | .5208 | −.0097 | .4812 | .4855 | .0043 |
| Anterior limb of internal capsule, right | .6311 | .6213 | −.0098* | .6242 | .6154 | −.0088* | .6215 | .6129 | −.0086* |
| Anterior limb of internal capsule, left | .6083 | .6194 | .0111* | .6024 | .6102 | .0079* | .6003 | .6116 | .0113* |
| Posterior limb of internal capsule, right | .6949 | .6903 | −.0046 | .6924 | .6859 | −.0065* | .6954 | .6906 | −.0048 |
| Posterior limb of internal capsule, left | .6934 | .6942 | .0008 | .6917 | .6903 | −.0014 | .6977 | .6953 | −.0024 |
| Retrolenticular part of internal capsule, right | .5807 | .5993 | .0186* | .5819 | .5901 | .0082 | .5834 | .5901 | .0066 |
| Retrolenticular part of internal capsule, left | .5985 | .5883 | −.0102* | .5951 | .5859 | −.0092* | .5935 | .5902 | −.0033 |
| Anterior corona radiata, right | .5192 | .5119 | −.0073 | .5150 | .5043 | −.0108* | .5056 | .4947 | −.0110* |
| Anterior corona radiata, left | .5037 | .5084 | .0047 | .4979 | .4980 | .0002 | .4885 | .4942 | .0057 |
| Superior corona radiata, right | .5267 | .5297 | .0030 | .5239 | .5240 | .0001 | .5186 | .5191 | .0006 |
| Superior corona radiata, left | .5319 | .5207 | −.0111* | .5261 | .5169 | −.0091* | .5235 | .5121 | −.0114* |
| Posterior corona radiata, right | .5172 | .5115 | −.0057 | .5094 | .4945 | −.0150* | .5062 | .4873 | −.0189* |
| Posterior corona radiata, left | .5010 | .5134 | .0125* | .4892 | .5018 | .0125* | .4835 | .4999 | .0163* |
| Posterior thalamic radiation, right | .6269 | .6260 | −.0009 | .6207 | .6162 | −.0045 | .6180 | .6081 | −.0099 |
| Posterior thalamic radiation, left | .6179 | .6255 | .0076 | .6105 | .6094 | −.0011 | .6011 | .6123 | .0111 |
| Sagittal stratuma, right | .5732 | .5744 | .0012 | .5687 | .5637 | −.0050 | .5656 | .5635 | −.0020 |
| Sagittal stratuma, left | .5706 | .5746 | .0040 | .5609 | .5625 | .0016 | .5617 | .5641 | .0024 |
| External capsule, right | .4769 | .4770 | .0001 | .4741 | .4690 | −.0050 | .4711 | .4679 | −.0032 |
| External capsule, left | .4731 | .4755 | .0024 | .4679 | .4698 | .0020 | .4652 | .4715 | .0063 |
| Cingulum (cingulate gyrus), right | .6104 | .6403 | .0299* | .6099 | .6333 | .0233* | .6072 | .6378 | .0305* |
| Cingulum (cingulate gyrus), left | .6391 | .6048 | −.0343* | .6344 | .6016 | −.0328* | .6344 | .6023 | −.0320* |
| Cingulum (hippocampus), right | .5556 | .5585 | .0029 | .5602 | .5393 | −.0210* | .5535 | .5445 | −.0090 |
| Cingulum (hippocampus), left | .5486 | .5702 | .0216* | .5421 | .5552 | .0131 | .5417 | .5599 | .0182* |
| Fornix, stria terminalis, right | .5581 | .5806 | .0225* | .5547 | .5701 | .0153* | .5454 | .5671 | .0217* |
| Fornix, stria terminalis, left | .5625 | .5562 | −.0063 | .5590 | .5433 | −.0156* | .5509 | .5426 | −.0084 |
| Superior longitudinal fasciculus, right | .5298 | .5313 | .0015 | .5325 | .5297 | −.0028 | .5320 | .5241 | −.0079 |
| Superior longitudinal fasciculus, left | .5303 | .5243 | −.0060 | .5305 | .5258 | −.0047 | .5271 | .5233 | −.0038 |
| Superior fronto-occipital fasciculus, right | .5380 | .5308 | −.0072 | .5329 | .5281 | −.0048 | .5214 | .5155 | −.0060 |
| Superior fronto-occipital fasciculus, left | .5276 | .5252 | −.0023 | .5189 | .5188 | −.0001 | .5097 | .5123 | .0026 |
| Uncinate fasciculus, right | .5523 | .5516 | −.0006 | .5393 | .5413 | .0019 | .5395 | .5387 | −.0008 |
| Uncinate fasciculus, left | .5263 | .5179 | −.0084 | .5109 | .5074 | −.0035 | .5071 | .5108 | .0037 |
| Tapetum, right | .6164 | .6121 | −.0042 | .5907 | .5824 | −.0083 | .5910 | .5714 | −.0196* |
| Tapetum, left | .6345 | .6343 | −.0002 | .6106 | .5983 | −.0124 | .5942 | .5812 | −.0130 |
Note: Δ = mean FA difference (mean FA follow-up − mean FA baseline), with values in italics representing FA decreases and bold representing FA increases. FA, fractional anisotropy.
aIncl. inferior longitudinal fasciculus and inferior fronto-occipital fasciculus.
*Results of a within-group paired t-test examining significant within group ΔFA differences per brain region (P < .05), accounting for a false discovery rate with the Simes’ procedure (38 regions × 3 groups) (*P Simes < .003).