Fig. 4.

Age dependence of intracellular NADH level (a) and RR (b) in chronic schizophrenia (SZ) (red filled circles) and matched controls (black filled circles). R-values = Pearson correlation coefficients. In order to visualize the whole trend of redox state age-dependence, data from FE SZ (red open circles) and matched controls (black open circles) are presented. The older healthy group was recruited age/sex-matched for the chronic SZ group, and the younger healthy group matched for the FE SZ group. Some of the chronic SZ patients are relatively young, close in age to some FE SZ patients, and likewise for older and younger healthy participants. In fact, a correlation with age that includes all healthy participants together (since they are all comparable) is nonsignificant (R = 0.268, P = .095 for NADH and R = 9.297, P = .062 for Redox Ratio [RR]). This finding requires further investigation in children and adolescents.