Figure 8. Nucleotide binding to the degenerate site stabilizes cross-NBD contacts of inward-facing TM287/288.
The interfaces between the NBDs were analyzed by the PISA server. (A) Analysis of AMP-PNP-Mg bound TM287/288 (PDB: 4Q4A), (B) analysis of apo TM287/288 (PDB: 4Q4A). The left panel shows a top view of the NBDs, the right panel a side view of the degenerate (front) and consensus (back) site. Cross-NBD hydrogen bonds and salt bridges according to the PISA server criteria are highlighted by dashed black lines.