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. 2016 May 17;7(30):46835–46847. doi: 10.18632/oncotarget.9390

Figure 5. Downregulation of Slfn2 attenuates preexisting T-cell lymphoma.

Figure 5

a. Flow cytometry analysis of Slfn2 expression in the EL4 lymphoma cell line stained with only secondary antibody (left panel), transduced with shSlfn2 (middle panel) or transduced with non-specific scrambled shRNA (right panel). b. Analysis of T-cell lymphoma development in Rag1−/− mice by the IVIS Kinetic Bioluminescent Fast Imaging system 13 days after EL4 cell line injection. Upper panel: Rag1−/− mice injected with EL4 cells that were previously transduced with non-specific scrambled shRNA lentivirus together with lentivirus expressing the luciferase reporter gene. Lower panel: Rag1−/− mice injected with EL4 cells that were previously transduced with Slfn2 shRNA together with lentivirus expressing the luciferase reporter gene. c. Survival curves of Rag1−/− mice injected with EL4 cells transduced with either Slfn2 shRNA (black) or non-specific scrambled shRNA (grey) lentivirus (n = 7).