Table 3. Top 12 significantly age acceleration related CpG sites in validation panel a.
| CpG sites | Genes | Mean (SD)b | Age acceleration (Horvath) | Age acceleration (Hannum) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Correlation coefficientsc | Effect size (SE)d | p-value | FDR | Correlation coefficientsc | Effect size (SE)d | p-value | FDR | |||
| cg03329539 | 2q37.1 | 0.38 (0.036) | −0.23 | −23.9 (6.0) | 8.7 e-5 | 2.0 e-4 | −0.27 | −16.6 (4.5) | 2.8 e-4 | 6.0 e-4 |
| cg01899089 | AHRR | 0.49 (0.033) | −0.30 | −41.0 (5.6) | 1.8 e-12 | 7.3 e-11 | −0.33 | −29.8 (4.3) | 9.9 e-12 | 1.6 e-10 |
| cg05575921 | AHRR | 0.85 (0.041) | −0.21 | −5.8 (2.1) | 5.3 e-3 | 8.2 e-3 | −0.25 | −5.5 (1.5) | 4.2 e-4 | 8.3 e-4 |
| cg24090911 | AHRR | 0.73 (0.034) | −0.20 | −28.9 (5.8) | 7.8 e-7 | 3.1 e-6 | −0.33 | −31.2 (4.2) | 5.6 e-13 | 1.5 e-11 |
| cg20295214 | AVPR1B | 0.76 (0.029) | −0.26 | −31.9 (6.6) | 1.6 e-6 | 6.2 e-6 | −0.27 | −24.9 (4.9) | 6.0 e-7 | 3.3 e-6 |
| cg10190813 | HUS1 | 0.17 (0.026) | −0.25 | −39.5 (9.5) | 4.1 e-5 | 9.6 e-5 | −0.23 | −18.8 (7.4) | 0.011 | 0.015 |
| cg01744331 | KCNQ1 | 0.90 (0.032) | −0.21 | −35.2 (6.9) | 4.8 e-7 | 2.0 e-6 | −0.25 | −25.3 (5.3) | 2.5 e-6 | 1.1 e-5 |
| cg07123182 | KCNQ1 | 0.93 (0.019) | −0.20 | −48.9 (8.7) | 4.2 e-8 | 2.7 e-7 | −0.25 | −41.4 (6.5) | 5.3 e-10 | 6.3 e-9 |
| cg06595162 | NCRNA00114 | 0.72 (0.026) | −0.24 | −48.5 (6.8) | 1.5 e-12 | 7.3 e-11 | −0.25 | −34.7 (5.1) | 4.7 e-11 | 6.5 e-10 |
| cg04158018 | NFE2 | 0.30 (0.040) | −0.21 | −24.5 (6.3) | 1.1 e-4 | 2.3 e-4 | −0.23 | −20.8 (4.7) | 9.4 e-6 | 3.3 e-5 |
| cg25305703 | 0.65 (0.051) | −0.29 | −23.6 (3.5) | 4.1 e-11 | 8.5 e-10 | −0.36 | −21.6 (2.5) | 2.8 e-16 | 1.2 e-14 | |
| cg16201146 | 0.67 (0.045) | −0.24 | −37.9 (6.4) | 7.4 e-9 | 6.2 e-8 | −0.20 | −41.5 (4.6) | 9.7 e-18 | 8.1 e-16 | |
a
12 loci with correlation coefficients ≤ −0.20;
b
Data of never smokers;
c
Spearman's Rank-Order Correlation coefficients;
d
Adjusted for age (years), gender, random batch effects, leukocyte distribution (Houseman algorithm [21]), alcohol consumption (abstainer/ low/ intermediate/ high), body mass index (BMI, underweight or normal weight/ overweight/ obese) and physical activity (inactive/ low/ medium or high); The beta coefficients from regression models were reported as effect sizes;