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. 2016 Jul 1;7(30):46899–46912. doi: 10.18632/oncotarget.10380

Table 1. The list of the proteins changed in Phospho Explorer Antibody Array.

ID (phosphorylation) Swiss Prot ID p-value (HNG vs. Water) Mean Ratio (HNG vs. Water) Fold Change (HNG vs. Water) Target Location Molecular Function
MEK1 (Phospho-Ser298) Q02750 0.00 1.47 1.47 Cytoplasm kinase
GSK3 beta (Phospho-Ser9) P49841 0.00 2.33 2.33 Nucleus kinase
Shc (Phospho-Tyr349) P29353 0.00 1.48 1.48 Cytoplasm kinase
NFkB-p65 (Phospho-Ser276) Q04206 0.00 0.74 −1.36 Nucleus transcription regulator
VEGFR2 (Phospho-Tyr1214) P35968 0.00 1.22 1.22 Plasma Membrane kinase
HDAC8 (Phospho-Ser39) Q9BY41 0.01 0.80 −1.25 Nucleus transcription regulator
Tau (Phospho-Ser356) P10636 0.01 1.62 1.62 Plasma Membrane other
CREB (Phospho-Ser121) P16220 0.01 0.66 −1.52 Nucleus transcription regulator
IL-2RA/CD25 (Phospho-Ser268) P01589 0.01 1.24 1.24 Plasma Membrane transmembrane receptor
ATPase (Phospho-Ser16) P05023 0.01 1.47 1.47 Plasma Membrane transporter
Raf1 (Phospho-Tyr341) P04049 0.01 0.73 −1.38 Cytoplasm kinase
EGFR (Phospho-Tyr1016) P00533 0.01 0.70 −1.42 Plasma Membrane kinase
BCL-XL (Phospho-Thr47) Q07817 0.01 2.31 2.31 Cytoplasm other
PLC-beta (Phospho-Ser1105) Q01970 0.01 1.39 1.39 Cytoplasm enzyme
Interferon-gamma receptor alpha chain precursor (Phospho-Tyr457) P15260 0.01 1.34 1.34 Plasma Membrane transmembrane receptor
SRF (Phospho-Ser99) P11831 0.02 1.27 1.27 Nucleus transcription regulator
Caspase 2 (Phospho-Ser157) P42575 0.02 0.68 −1.46 Cytoplasm peptidase
p53 (Phospho-Ser46) P04637 0.02 1.37 1.37 Nucleus transcription regulator
Histone H2A.X (Phospho-Ser139) P16104 0.02 1.53 1.53 Nucleus transcription regulator
AMPK1 (Phospho-Thr174) Q13131 0.02 1.84 1.84 Cytoplasm kinase
Mnk1 (Phospho-Thr385) Q9BUB5 0.02 1.57 1.57 Cytoplasm kinase
EGFR (Phospho-Ser1070) P00533 0.02 1.88 1.88 Plasma Membrane kinase
IRS-1 (Phospho-Ser639) P35568 0.02 1.82 1.82 Cytoplasm enzyme
p53 (Phospho-Ser315) P04637 0.02 1.97 1.97 Nucleus transcription regulator
IkB-epsilon (Phospho-Ser22) O00221 0.02 1.50 1.50 Nucleus transcription regulator
Tau (Phospho-Ser235) P10636 0.02 1.57 1.57 Plasma Membrane other
ATF2 (Phospho-Thr71/53) P15336 0.02 0.83 −1.21 Nucleus transcription regulator
eIF4G (Phospho-Ser1108) Q04637 0.02 1.30 1.30 Cytoplasm translation regulator
Calmodulin (Phospho-Thr79/Ser81) P62158 0.02 1.35 1.35 Cytoplasm other
MSK1 (Phospho-Thr581) O75582 0.02 1.23 1.23 Nucleus kinase
STAT5B (Phospho-Ser731) P51692 0.03 1.34 1.34 Nucleus transcription regulator
FAK (Phospho-Ser910) Q05397 0.03 1.79 1.79 Cytoplasm kinase
Catenin beta (CTNNB) (Phospho-Tyr489) P35222 0.03 0.66 −1.52 Nucleus transcription regulator
GSK3 alpha (Phospho-Ser21) P49840 0.03 2.96 2.96 Nucleus kinase
MKK3 (Phospho-Ser189) P46734 0.03 1.29 1.29 Cytoplasm kinase
CDC2 (Phospho-Tyr15) P06493 0.03 1.28 1.28 Nucleus kinase
LYN (Phospho-Tyr507) P07948 0.03 1.97 1.97 Cytoplasm kinase
Cyclin D1 (Phospho-Thr286) P24385 0.03 0.64 −1.56 Nucleus transcription regulator
KSR (Phospho-Ser392) Q8IVT5 0.03 1.43 1.43 Cytoplasm kinase
PDGF R alpha (Phospho-Tyr849) P16234 0.03 0.73 −1.37 Plasma Membrane kinase
p21Cip1 (Phospho-Thr145) P38936 0.03 0.69 −1.45 Nucleus kinase
NFAT4 (Phospho-Ser165) Q12968 0.03 0.66 −1.51 Nucleus transcription regulator
PKC zeta (Phospho-Thr410) Q05513 0.04 1.75 1.75 Cytoplasm kinase
4E-BP1 (Phospho-Thr70) Q13541 0.04 1.23 1.23 Cytoplasm translation regulator
CDC25A (Phospho-Ser75) P30304 0.04 1.54 1.54 Nucleus phosphatase
p44/42 MAP Kinase (Phospho-Tyr204) P27361/P28482 0.04 1.79 1.79 Cytoplasm kinase
SEK1/MKK4 (Phospho-Thr261) P45985 0.04 1.25 1.25 Cytoplasm kinase
Synapsin (Phospho-Ser9) P17600 0.04 1.30 1.30 Plasma Membrane transporter
c-Jun (Phospho-Ser73) P05412 0.04 0.64 −1.55 Nucleus transcription regulator
STAT3 (Phospho-Ser727) P40763 0.04 1.23 1.23 Nucleus transcription regulator
Caspase 9 (Phospho-Ser196) P55211 0.04 1.59 1.59 Cytoplasm peptidase
SEK1/MKK4 (Phospho-Ser80) P45985 0.04 1.25 1.25 Cytoplasm kinase
STAT6 (Phospho-Thr645) P42226 0.04 1.47 1.47 Nucleus transcription regulator
Pyk2 (Phospho-Tyr580) Q14289 0.04 1.32 1.32 Cytoplasm kinase
CK2-b (Phospho-Ser209) P67870 0.05 1.26 1.26 Cytoplasm kinase
CDK5 (Phospho-Tyr15) Q00535 0.05 2.30 2.30 Nucleus kinase
Paxillin (Phospho-Tyr118) P49023 0.05 0.77 −1.30 Cytoplasm other
PAK1 (Phospho-Ser204) Q13153 0.05 1.52 1.52 Cytoplasm kinase
IkB-alpha (Phospho-Ser32/36) P25963 0.05 1.23 1.23 Cytoplasm transcription regulator
Estrogen Receptor-α (Phospho-Ser118) P03372 0.05 1.27 1.27 Nucleus ligand-dependent nuclear receptor