Figure 7. Structure of thiacremonone and activated p38, and binding of thiacremonone to activated p38.

Structure of thiacremonone, a sulfurcompound isolated from garlic A. Whole cell lysates of BV-2 were incubated with thiacremonone-conjugated Sepharose 6B. After precipitation, the levels of bound activated p38 were monitored by Western blot analysis B. Ribbon representation docking model of thiacremonone with activated p38 and Molecular surface representation docking model of thiacremonone with activated p38 C.