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. 2016 Jun 7;7(30):47095–47110. doi: 10.18632/oncotarget.9903

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Copyright: © 2016 Nettersheim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Quantification of 5mC levels in tumors from xenografted TCam-2-ΔSOX2 clones, TCam-2 and 2102EP cells. In vitro cultivated TCam-2 and 2102EP served as controls. (B) Commonly expressed genes in TCam-2-ΔSOX2 (vs. TCam-2 in vitro) and non-seminomas (n = 7) (vs. seminomas (n = 4)) based on microarray data. Green labeled genes are related to FOXA2. (C) STRING analysis of FOXA2 interacting genes. (D) Co-IP experiment in TCam-2 demonstrating binding of SOX17 to OCT3/4. (E) ChIP experiment in TCam-2, demonstrating binding of SOX17 to the SOX2 / OCT3/4 binding motif within the NANOG promoter.