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. 2016 Jun 15;7(30):47287–47301. doi: 10.18632/oncotarget.10075

Figure 1. Diagrams of pIX-zipper-TRAIL configuration and Ad vector genomes depicting tumor targeting strategy.

Figure 1

(A) Schematic of proposed Ad vector targeting approach showing Ad-mediated TRAIL expression and secretion, followed by cell lysis, Ad virion release and extracellular formation of a targeted Ad vector/TRAIL complex. (B) Configuration of heterodimeric zipper domains, in which one zipper domain was genetically incorporated into the C-terminus of pIX, and its counterpart was fused to the N-terminus of a recombinant TRAIL molecule. (C) Schematic diagram of recombinant Ads depicting the organization of elements. A0, rAd5-RFP; A1, rAd5-zTRAIL-RFP; A2, rAd5pz-zTRAIL-RFP; A3, rAd5-zTRAIL-RFP-Δ24E1a; A4, rAd5pz-zTRAIL-RFP-Δ24E1a.