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. 2016 Jun 17;7(30):47343–47365. doi: 10.18632/oncotarget.10121

Figure 2. Inhibition of HMG-CoA induces apoptosis of MOSEC in vitro.

Figure 2

(A) Simvastatin treatment of ID8 and 28-2 cells induce apoptotic cell death measured by the TUNEL assay in a dose-dependent manner. TUNEL positive cells (yellow) exhibit characteristic pyknotic morphology characterizing apoptotic cells. Cells were fixed on coverslips 24 hrs after simvastatin treatment. (B) Analysis of percentage of TUNEL positive cells reveals a significant (*p < 0.001) increase in higher doses of simvastatin when compared to controls (SF). N = 3, one-way ANOVA, Dunette's poc hoc test. SF - serum free control, VEH - simvastatin vehicle control, 0.1 μM – 0.1 μM dose of simvastatin, TUNEL - terminal deoxynucleotidyl transferase dUTP nick end labeling.