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. 2016 Jun 17;7(30):47343–47365. doi: 10.18632/oncotarget.10121

Figure 3. Mevalonic acid, but not cholesterol can rescue EOC cell lines from simvastatin induced cell death.

Figure 3

Treatment of 500 μM mevalonic acid (MEV) rescues various mouse (ID8, 28-2, 30-2) and human (SKOV3, OVCAR3) cell lines from 20 μM simvastatin cell death determined by viability assay. Administration of water-soluble cholesterol (CHOL) did not rescue all cell lines tested from simvastatin induced cell death. SF - serum free, NOSE - normal ovarian surface epithelial cells, SIM VEH - simvastatin vehicle control, MEV VEH - mevalonic acid vehicle control, SQUAL - squalene.