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. 2016 Jun 17;7(30):47343–47365. doi: 10.18632/oncotarget.10121

Figure 6. Simvastatin induces regression of advanced stage ovarian cancer.

Figure 6

Tumors were orthotopically induced with ID8 cells in syngeneic mice and allowed to grow until 60 d PTI at which time they received daily IP injections of PBS or simvastatin (1 mg/kg/d) for 20 d. (A) Tumors from mice treated with simvastatin had regressed to a significantly (*p < 0.05) smaller size, compared to PBS treated controls. (B) Simvastatin treated mice had a significant (*p < 0.05) reduction in percentage of viable ovarian cancer cells collected from ascites. (C) Simvastatin treatment reduced the number of metastatic peritoneal tumors, compared to PBS treated controls.