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. 2016 Jun 17;7(30):47366–47375. doi: 10.18632/oncotarget.10144

Table 2. Associations between smoking behavior–related SNPs and melanoma risk.

SNP CHR Gene Reference Number Allc Menc Womenc CytoBand
Risk Ref Allele frequency OR 95% CI P OR 95% CI P OR 95% CI P
rs215605a 7 PDE1C [30] G T 0.38 1.01 0.92–1.10 0.9 0.99 0.88–1.12 0.88 1.01 0.89–1.15 0.85 7p14.3
rs11782673b 8 PTK2B [17] G A 0.17 1.09 0.97–1.22 0.14 1.02 0.87–1.19 0.85 1.14 0.98–1.33 0.09 8p21.2
rs6474412a 8 SMIM19, CHRNB3 [30] C T 0.23 1.02 0.93–1.13 0.63 1.13 0.98–1.3 0.09 0.92 0.8–1.07 0.28 8p11.21
rs13280604a 8 CHRNB3 [30] G A 0.23 1.02 0.92–1.13 0.69 1.12 0.97–1.28 0.13 0.93 0.8–1.07 0.30 8p11.21
rs7872903a 9 FAM163B, DBH [15] C T 0.21 1.00 0.91–1.11 0.98 1.01 0.88–1.17 0.88 0.99 0.86–1.14 0.91 9q34.2
rs1329650a 10 HECTD2-AS1 [15] T G 0.28 0.97 0.88–1.07 0.54 1.00 0.87–1.14 1.00 0.95 0.83–1.08 0.43 10q23.32
rs1013442a 11 BDNF-AS [15] T A 0.25 1.02 0.92–1.13 0.67 1.09 0.95–1.26 0.22 0.97 0.84–1.11 0.66 11p14.1
rs6265a 11 BDNF [15] T C 0.19 1.04 0.94–1.16 0.44 1.13 0.97–1.32 0.10 0.97 0.83–1.13 0.67 11p14.1
rs2036534b 15 HYKK [30] C T 0.22 1.14 1.03–1.26 0.01 1.20 1.04–1.38 0.01 1.07 0.93–1.24 0.33 15q25.1
rs588765b 15 CHRNA5 [14, 17] T C 0.42 1.02 0.94–1.11 0.59 1.03 0.91–1.16 0.64 1.00 0.89–1.13 1.00 15q25.1
rs16969968a 15 CHRNA5 [15, 17, 30] A G 0.35 0.91 0.83–0.99 0.03 0.85 0.75–0.96 0.01 0.99 0.87–1.12 0.86 15q25.1
rs578776a 15 CHRNA3 [14] A G 0.28 1.08 0.99–1.18 0.1 1.20 0.87–1.66 0.27 1.01 0.89–1.15 0.85 15q25.1
rs1051730a 15 CHRNA3 [15, 17, 30] A G 0.34 0.91 0.84–1.00 0.05 0.86 0.76–0.98 0.02 0.99 0.88–1.13 0.92 15q25.1
rs6495308a 15 CHRNA3 [17] C T 0.23 1.08 0.98–1.20 0.11 1.19 1.03–1.36 0.01 0.99 0.86–1.14 0.89 15q25.1
rs7937a 19 MIA-RAB4B [30] C T 0.44 0.94 0.86–1.02 0.13 0.86 0.76–0.97 0.01 1.02 0.91–1.15 0.70 19q13.2
rs3733829a 19 RAB4B-EGLN2 [15] G A 0.36 0.96 0.88–1.04 0.32 0.95 0.84–1.07 0.38 0.96 0.84–1.08 0.47 19q13.2

Abbreviations: CHR, chromosome; OR, odds ratio; SNP, single-nucleotide polymorphism.

a

SNPs reached genome-wide signifcance (P value = 5 × 10−8) with smoking behaviors.

b

SNPs did not reach P value of 5 × 10−8.

c

Meta-analysis results for both NHS and HPFS set and MD Anderson set.