Table 4. Associations between smoking behavior–related SNPs and smoking behaviors among controls of NHS and HPFS.

SNP	Risk	Ref	Related Smoking Phenotypes From Literaturea	CPDb,c			Smoking Cessationb,c			Smoking Initiationb,c			Pack Yearsb,c			Years since Quit Smokingb,c
				β	s.e.	P	β	s.e.	P	β	s.e.	P	β	s.e.	P	β	s.e.	P
rs215605	G	T	Smoking quantity	−0.002	0.038	0.952	0.113	0.072	0.118	−0.056	0.041	0.176	−0.165	0.536	0.758	0.003	0.027	0.912
rs11782673	G	A	Smoking quantity	−0.036	0.049	0.468	0.064	0.093	0.491	−0.028	0.054	0.596	−0.785	0.698	0.261	0.005	0.035	0.883
rs6474412	C	T	Smoking quantity	−0.098	0.043	0.022	0.072	0.081	0.376	0.039	0.048	0.410	−1.263	0.608	0.038	−0.005	0.030	0.879
rs13280604	G	A	Smoking quantity	−0.094	0.043	0.028	0.073	0.082	0.368	0.041	0.048	0.394	−1.244	0.608	0.041	−0.002	0.030	0.960
rs7872903	C	T	Smoking cessation	0.051	0.044	0.250	−0.110	0.082	0.179	0.030	0.049	0.534	0.921	0.626	0.142	−0.041	0.032	0.196
rs1329650	T	G	Smoking quantity	0.023	0.041	0.571	−0.083	0.076	0.276	0.008	0.045	0.857	0.502	0.579	0.386	0.010	0.029	0.731
rs1013442	T	A	Smoking initiation	0.084	0.042	0.044	−0.130	0.077	0.092	−0.051	0.046	0.265	1.274	0.589	0.031	0.028	0.029	0.341
rs6265	T	C	Smoking initiation	0.092	0.046	0.045	−0.201	0.084	0.017	−0.034	0.050	0.494	1.723	0.646	0.008	0.018	0.033	0.585
rs2036534	C	T	Smoking quantity	−0.143	0.044	0.001	0.184	0.086	0.033	−0.048	0.048	0.318	−1.649	0.626	0.009	−0.024	0.031	0.434
rs588765	T	C	Smoking quantity	−0.021	0.037	0.564	−0.023	0.069	0.735	0.069	0.040	0.086	−0.507	0.518	0.328	−0.025	0.026	0.327
rs16969968	A	G	Smoking quantity	0.099	0.038	0.009	−0.085	0.071	0.234	−0.070	0.042	0.091	1.699	0.536	0.002	0.036	0.027	0.178
rs578776	A	G	Smoking quantity	−0.072	0.040	0.075	0.141	0.078	0.070	−0.029	0.044	0.508	−0.992	0.571	0.083	−0.008	0.028	0.785
rs1051730	A	G	Smoking quantity	0.097	0.038	0.011	−0.107	0.072	0.134	−0.082	0.042	0.051	1.743	0.540	0.001	0.041	0.027	0.134
rs6495308	C	T	Smoking quantity	−0.100	0.043	0.021	0.181	0.084	0.032	0.005	0.047	0.915	−1.584	0.611	0.010	−0.018	0.030	0.557
rs7937	C	T	Smoking quantity	−0.027	0.037	0.467	−0.170	0.069	0.014	0.064	0.040	0.109	0.504	0.522	0.334	0.000	0.026	0.988
rs3733829	G	A	Smoking quantity	−0.071	0.037	0.059	0.050	0.071	0.488	−0.004	0.041	0.928	−0.270	0.531	0.611	−0.018	0.026	0.503

^a[14, 15, 17, 30].

^bCPD, pack years, and years since quit smoking was analyzed as a continuous variable representing the number of cigarettes smoked per day, number of multiplying years of smoking by the number of cigarettes divided by 20, years since quit smoking in former smokers, respectively. Smoking initiation and smoking cessation were analyzed as dichotomous variables, contrasting ever versus never and former versus current smokers, respectively.

^cAnalyses were adjusted by age, sex and fve EVs.