Figure 6. miR-10b is a key regulator for of migration and invasion capacity in aggressive CD49f⁺/CD44⁺/CD24⁻ single-cell derived clones.

(A) Comparative human breast cancer-associated microRNA expression levels in S2B11 and S2D10 clones. (B–D) Invasion capacity (B), migration capacity (Bar scale represents 25 μm) (C) and mammosphere formation ability (Bar scale represents 50 μm) (D) of S2B11, S2G7, S2D10 and S2F10 was evaluated after knocking-down the miR-10b in S2B11 and S2G7 clones with sponge miR-10b and overexpressing the miR-10b in S2D10 and S2F10 clones. Data represents the mean ± S.D (n = 2); ^*p < 0.05, ^**p < 0.01.