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. 2016 Jun 24;7(30):47760–47776. doi: 10.18632/oncotarget.10283

Figure 7. Elevated plasma miR-27a reflects unfavorable renal function and increased tubulointerstitial fibrosis in DN patients.

Figure 7

(A) Increased plasma miR-27a level in DN patients (n = 30) compared with healthy normal controls (n = 30). (B) Positive correlation between plasma miR-27a and serum creatinine, (C) proteinuria, (D) urinary NAG. (E) Negative correlation between plasma miR-27a and eGFR. (F) Decreased PPARγ expression and increased TGF-β1, p-Smad3, CTGF, Fibronectin, and Collagen I in renal biopsies of DN patients (n = 72) by immunohistochemistry (scale bar 100 μm) and quantification of the staining intensity. (G) Worsened tubulointerstitial fibrosis in DN compared with normal controls by Masson' s trichrome stain (scale bar 100 μm) and the quantification analysis. Results are presented as mean ± SD of three independent experiments. *P < 0.05; #P < 0.001. NC, normal control; DN, diabetic nephropathy; Scr, serum creatinine; NAG, N-acetyl-β-D-glucosaminidase (NAG); eGFR, estimated glomerular filtration rate; p-SMAD3, phospho-SMAD3; MTS, Masson' s trichrome stain.