Figure 8. A hypothetical model illustrating that miR-27a/PPARγ signaling regulated renal tubulointerstitial fibrosis through the TGF-β1/Smad3 mediated fibrosis in diabetic nephropathy.
MiR-27a inhibits PPARγ and aggravates tubulointerstitial fibrosis and progression of DN through activating TGF-β1/Smad3 signaling pathway and promoting the expression of CTGF, Fibronectin, and Collagen I.