Table 2. Biological parameters for diabetic rats treated with miR-27a mimics at week 12.
| Variables | DM_miR-NC (n = 7) | DM_miR-27am (n = 7) |
|---|---|---|
| Scr (umol/L) | 112.24 ± 6.38 | 122.30 ± 7.26* |
| Serum BUN (mmol/L) | 16.12 ± 4.06 | 19.27 ± 2.62* |
| Blood glucose (mmol/L) | 27.52 ± 0.76 | 25.54 ± 1.85 |
| Urinary NAG (U/L) | 37.26 ± 6.58 | 58. 36 ± 7.35# |
| UAER (ug/min) | 1.48 ± 0.25 | 2.85 ± 0.92# |
| UACR (ug/mmol) | 25.65 ± 2.18 | 58.67 ± 3.34# |
| Ccr (mL·min−1·Kg−1) | 3.12 ± 0.34 | 0.68 ± 0.05# |
DM_miR-NC, diabetic rats treated with miRNA mimics negative control; DM_miR-27am, diabetic rats treated with miR-27a mimics; Scr, serum creatinine; Serum BUN, serum blood urea nitrogen; Urinary NAG, urinary N-acetyl-β-D-glucosaminidase; UAER, urine albumin excretion rate; UACR, urine albumin to creatinine ratio; Ccr, creatinine clearance rate;
*
P < 0.01;
#
P < 0.001.