Table 1. Associations between the expression of calpastatin, calpain-1 and calpain-2 determined in core biopsy samples with clinicopathological variables also determined from the core biopsy samples.
| Calpastatin | Calpain-1 | Calpain-2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | P value | Low | High | P value | Low | High | P value | |
| Lymph node status | |||||||||
| Negative | 26 (28.6%) | 18 (19.8%) | 0.442 | 30 (35.3%) | 12 (14.1%) | 0.867 | 30 (33.0%) | 15 (16.5%) | 0.565 |
| Positive | 24 (26.4%) | 23 (25.3%) | 30 (35.3%) | 13 (15.3%) | 28 (30.8%) | 18 (19.8%) | |||
| Pathological response | |||||||||
| None/minimal | 10 (6.6%) | 2 (1.7%) | 0.081 | 7 (6.4%) | 2 (1.8%) | 0.250 | 6 (5.1%) | 6 (5.1%) | 0.593 |
| Partial | 43 (37.1%) | 43 (37.1%) | 53 (48.6%) | 29 (26.6%) | 56 (47.9%) | 31 (26.5%) | |||
| Complete | 11 (9.5%) | 7 (6.0%) | 15 (13.8%) | 3 (2.8%) | 12 (10.3%) | 6 (5.1%) | |||
| Inflammatory disease | |||||||||
| Non-inflammatory | 49 (36.6%) | 43 (32.1%) | 0.350 | 58 (46.4%) | 28 (22.4%) | 0.932 | 64 (47.4%) | 30 (22.2%) | 0.109 |
| Inflammatory | 26 (19.4%) | 16 (11.9%) | 26 (20.8%) | 13 (10.4%) | 22 (16.3%) | 19 (14.1%) | |||
| Tumour grade | |||||||||
| 1 | 3 (2.6%) | 3 (2.6%) | 0.825 | 5 (4.6%) | 1 (0.9%) | 0.596 | 3 (2.6%) | 3 (2.6%) | 0.365 |
| 2 | 29 (25.2%) | 21 (18.3%) | 29 (26.6%) | 14 (12.8%) | 27 (23.3%) | 22 (19.0%) | |||
| 3 | 31 (27.0%) | 28 (24.3%) | 38 (34.9%) | 37 (33.9%) | 41 (35.3%) | 20 (17.2%) | |||
| ER status | |||||||||
| Negative | 36 (26.9%) | 17 (12.7%) | 0.017 | 38 (30.4%) | 13 (10.4%) | 0.111 | 35 (25.9%) | 19 (14.1%) | 0.716 |
| Positive | 38 (28.4%) | 43 (32.1%) | 45 (36.0%) | 29 (23.2%) | 50 (37.0%) | 31 (23.0%) | |||
| PgR status | |||||||||
| Negative | 40 (29.9%) | 27 (20.1%) | 0.297 | 48 (38.4%) | 15 (12.0%) | 0.019 | 46 (34.1%) | 23 (17.0%) | 0.362 |
| Positive | 34 (25.4%) | 33 (24.6%) | 35 (28.0%) | 27 (21.6%) | 39 (28.9%) | 27 (20.0%) | |||
| HER2 status | |||||||||
| Negative | 39 (41.9%) | 33 (35.5%) | 0.885 | 50 (57.5%) | 20 (23.0%) | 0.587 | 45 (48.4%) | 26 (28.0%) | 0.717 |
| Positive | 11 (11.8%) | 10 (10.8%) | 11 (12.6%) | 6 (6.9%) | 13 (14.0%) | 9 (9.7%) | |||
The P values are resultant from Pearson χ2 test of association or Fishers Exact when an asterisk is included. Significant P values are indicated in bold. ER is oestrogen receptor and PgR is progesterone receptor.