Table 2. Associations between the expression of calpastatin, calpain-1 and calpain-2 determined in surgically excised samples with clinicopathological variables also determined from the surgically excised samples.
| Calpastatin | Calpain-1 | Calpain-2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | P value | Low | High | P value | Low | High | P value | |
| Lymph node status | |||||||||
| Negative | 17 (37.0%) | 2 (4.3%) | 0.086* | 11 (22.9%) | 8 (16.7%) | 0.675 | 12 (25.5%) | 6 (12.8%) | 0.869 |
| Positive | 17 (37.0%) | 10 (21.7%) | 15 (31.3%) | 14 (29.2%) | 20 (42.6%) | 9 (19.1%) | |||
| Pathological response | |||||||||
| None/minimal | 8 (15.1%) | 1 (1.9%) | 0.418* | 6 (10.2%) | 4 (6.8%) | 0.506* | 8 (14.0%) | 2 (3.5%) | 0.295* |
| Partial | 30 (56.6%) | 14 (26.4%) | 23 (39.0%0 | 26 (44.1%) | 28 (49.1%) | 19 (33.3%) | |||
| Inflammatory disease | |||||||||
| Non-inflammatory | 31 (56.4%) | 12 (21.8%) | 0.730* | 25 (41.0%) | 21 (34.4%) | 0.334 | 32 (53.3%) | 13 (21.7%) | 0.009 |
| Inflammatory | 8 (14.5%) | 4 (7.3%) | 6 (9.8%) | 9 (14.8%) | 5 (8.3%) | 10 (16.7%) | |||
| Tumour grade | |||||||||
| 1 | 3 (6.0%) | 1 (2.0%) | 0.774 | 1 (1.9%) | 3 (5.8%) | 0.227 | 2 (3.8%) | 2 (3.8%) | 0.841 |
| 2 | 14 (28.0%) | 7 (14.0%) | 8 (15.4%) | 14 (26.9%) | 15 (28.8%) | 8 (15.4%) | |||
| 3 | 19 (38.0%) | 6 (12.0%) | 15 (28.8%) | 11 (21.2%0 | 16 (30.8%0 | 9 (17.3%) | |||
| ER status | |||||||||
| Negative | 14 (26.4%) | 5 (9.4%) | 0.990 | 11 (19.3%) | 10 (17.5%) | 0.707 | 15 (27.3%) | 6 (10.9%) | 0.606 |
| Positive | 25 (47.2%) | 9 (17.0%) | 17 (29.8%) | 19 (33.3%) | 22 (40.0%) | 12 (21.8%) | |||
| PgR status | |||||||||
| Negative | 19 (35.8%) | 7 (13.2%) | 0.934 | 16 (28.1%) | 12 (21.1%) | 0.234 | 20 (36.4%) | 8 (14.5%) | 0.504 |
| Positive | 20 (37.7%) | 7 (13.2%) | 12 (21.1%) | 17 (29.8%) | 17 (30.9%) | 10 (18.2%) | |||
| HER2 status | |||||||||
| Negative | 37(71.2%) | 14 (26.9%) | 0.288* | 29 (52.7%) | 25 (45.5%) | 0.473* | 37 (68.5%) | 16 (29.6%) | 0.315* |
| Positive | 0 (0.0%) | 1 (1.9%) | 0 (0.0%) | 1 (1.8%) | 0 (0.0%) | 1 (1.9%) | |||
| Size | |||||||||
| less than 2cm | 14 (30.4%) | 1 (2.2%) | 0.070* | 11 (22.9%) | 6 (12.5%) | 0.278 | 10 (21.3%) | 6 (12.8%) | 0.555 |
| 2cm or greater | 20 (43.5%) | 11 (23.9%) | 15 (31.3%) | 16 (33.3%) | 22 (46.8%) | 9 (19.1%) | |||
The P values are resultant from Pearson χ2 test of association or Fishers Exact when an asterisk is included. Significant P values are indicated in bold. ER is oestrogen receptor and PgR is progesterone receptor.